An Improved Model of Voltage- and Ca-Dependent Inactivation of the L-Type Ca Channels

Ca(2+)-dependent inactivation of cardiac L-type Ca2+ channels does not affect their voltage sensor

Inactivation of currents carried by Ba2+ and Ca2+, as well as intramembrane charge movement from L-type Ca2+ channels were studied in guinea pig ventricular myocytes using the whole-cell patch clamp technique. Prolonged (2 s) conditioning depolarization caused substantial reduction of charge movement between -70 and 10 mV (charge 1, or charge from noninactivated channels). In parallel, the char...

Ca/Calmodulin-Dependent Facilitation and Inactivation of P/Q-Type Ca Channels

Trains of action potentials cause Ca-dependent facilitation and inactivation of presynaptic P/Q-type Ca channels that can alter synaptic efficacy. A potential mechanism for these effects involves calmodulin, which associates in a Ca-dependent manner with the pore-forming a1A subunit. Here, we report that Ca and calmodulin dramatically enhance inactivation and facilitation of P/Q-type Ca channel...

Adrenergic Signaling Controls RGK-Dependent Trafficking of Cardiac Voltage-Gated L-Type Ca Channels Through PKD1

the investigation of the relationship between type a and type b personalities and quality of translation

چکیده ندارد.

Cav1.4 1 Subunits Can Form Slowly Inactivating Dihydropyridine-Sensitive L-Type Ca Channels Lacking Ca -Dependent Inactivation

The neuronal L-type calcium channels (LTCCs) Cav1.2 1 and Cav1.3 1 are functionally distinct. Cav1.3 1 activates at lower voltages and inactivates more slowly than Cav1.2 1, making it suitable to support sustained L-type Ca 2 inward currents (ICa,L ) and serve in pacemaker functions. We compared the biophysical and pharmacological properties of human retinal Cav1.4 1 using the whole-cell patchc...